FIGURE

Fig. 5

ID

ZDB-FIG-091215-42

Publication

Reischauer et al., 2009 - Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Phylogenetic analysis of erbB family members and zebrafish mutants of erbB paralogs.

(A) Phylogenetic analysis of erbB family members in the zebrafish genome (zv7) with the human orthologs (Minimum evolution algorithm, 100 replicates). With the exception of erbB2, all other erbB family members are duplicated in zebrafish. (B–D) DIC Images of wild-type (B), erbB2^-/- (C) and erbB3b^-/- (D) larvae at 132hpf. (E) In-situ hybridization analysis of erbB2 at 48hpf. Keratin staining in erbB3b mutant larva (F) erbB3b/lgl2 double mutant larva (G) and pen/lgl2 mutant larva (H) at 132 hpf. Note that in erbB3B;lgl2 double mutants (G) epidermal cells appear spindle shaped as in pen/lgl2 mutant larvae (H). erbB3b (F) mutations alone do not affect the morphology of basal epidermal cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.