FIGURE

Fig. S1

ID

ZDB-FIG-091214-15

Publication

Bonkowsky et al., 2008 - Domain-specific regulation of foxP2 CNS expression by lef1

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Fig. S1

Loss of lef1 leads to absent foxP2 expression in the tectum, mid-hindbrain boundary, and hindbrain. Whole-mount in situs at 48 hpf; anterior to left, dorsal up, eyes removed. Scale bar = 50 μm. (Conditions: hs:Δtcf- Tg(hsp70l:Δtcf:GFP)^w26, lef1 mo- lef1 morphants, wt- wild type, x8- homozygous Df(LG01)^x8. Abbreviations: hb: hindbrain; mhb: mid-hindbrain boundary; tec: tectum; tel: telencephalon.) (A, B) lef1 morphant (B) lacks expression in tectum and has diminished expression in the hindbrain (arrows), compared to wild-type (A). (C) In Df(LG01)^x8homozygote, expression is absent in the tectum and hindbrain (arrows). (D) In Tg(hsp70l:Δtcf:GFP)^w26embryo, collected four hours after heat shocking, expression is absent from the tectum and hindbrain (arrows). MHB expression is reduced but not absent, perhaps because lef1 induction of foxP2 expression is already sufficiently established by the time of heat-shock.

Expression Data

Gene:	foxp2
Fish:	WT WT + MO2-lef1 w26Tg Df(Chr01:lef1,msxb)x8/x8
Condition:	heat shock
Knockdown Reagent:	MO2-lef1
Anatomical Terms:	hindbrain optic tectum telencephalon
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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