FIGURE

Fig. 9

ID

ZDB-FIG-091125-8

Publication

Schier et al., 1996 - Mutations affecting the development of the embryonic zebrafish brain

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Fig. 9

Phenotypic analysis of mind bomb (mib) mutants. (A,C,E,G) Wild type. (B,D,F,H) mind bomb (mib)^m178 mutants. (A,B) Brain in wild-type (A) and mutant (B) embryos at 25-somite stage. Note the irregularities in the hindbrain (arrowhead). (C,D) Expression of islet1 in wild-type (C) and mutant (D) embryos at 13-somite stage. Note the dramatic increase of islet1-expressing cells in all regions where primary neurons are formed, including the spinal cord, epiphysis (arrow) and trigeminal ganglion. (E,F) Dorsal view of prospective Rohon-Beard cells (arrow) in dorsal spinal cord of embryos shown in C and D. (G,H) Mauthner neurons (arrow) in wild type (G) and mutant (H) embryos at 28 hpf, highlighted by 3A10 antibody. Note the abnormal projection of the most laterally located supernumerary Mauthner cell in this mutant embryo. All the other Mauthner cells project towards the midline.

Expression Data

Gene:	isl1a
Antibody:	Ab-3A10
Fish:	AB mib1^m178/m178 (AB)
Anatomical Terms:	epiphysis primary neuron Mauthner neuron spinal cord neural rod primary neuron spinal cord neural rod Rohon-Beard neuron trigeminal placode primary neuron
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mib1^m178/m178 (AB)
Observed In:	hindbrain neurogenesis
Stage Range:	10-13 somites to Prim-5

Phenotype Detail

Acknowledgments

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