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Fig. S3

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ZDB-FIG-090527-47

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North et al., 2009 - Hematopoietic stem cell development is dependent on blood flow

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Fig. S3

The silent heart mutation does not affect primitive hematopoiesis or mesodermal and endodermal development at 36 hpf.
(A-D) In situ hybridization (n>25 per treatment) for globin and myeloperoxidase (mpo) demonstrates pooling of blood cells due to the absent heartbeat, but no quantitative changes for primitive erythropoiesis or myelopoiesis in sih mutants.
(E,F) Somite formation as depicted by in situ hybridization for myosin heavy chain (mhc) is normal in sih mutants, indicating that other mesodermal organs develop normally.
(G,H) Endoderm development, visualized by foxa3 expression, is not affected in sih mutants.

Expression Data

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Antibody Labeling

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Acknowledgments

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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell