FIGURE

Fig. 4

ID

ZDB-FIG-090501-63

Publication

de Pater et al., 2009 - Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

Other Figures

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Fig. 4

Cardiac defects of isl1^K88X mutant embryos. (A) Cartoon of the Isl1 protein with the location of the premature stop codon (K88X) identified in the isl1 mutant. (B) DNA sequence of a homozygous wild-type sibling (top) and a homozygous isl1^K88X mutant (bottom) at the site of the mutation (AAG>TAG) that results in a premature stop codon. (C) The number of heart beats per minute measured at 24, 48 and 72 hpf of wild-type sibling (black squares) and isl1 mutant (white squares) embryos. (D,E) In situ hybridization for bmp4 on 48 hpf wild-type sibling (D) and isl1 mutant (E) embryos. Black arrow (D) indicates bmp4 expression in the sinus venosus of a wild-type embryo; red arrow (E) indicates the inflow area of a representative isl1 mutant embryo lacking bmp4 expression. Embryos are shown as frontal-ventral views (OFT to the top).

Expression Data

Gene:	bmp4
Fish:	WT isl1a^sa29/sa29
Anatomical Terms:	atrioventricular canal bulbus arteriosus sinus venosus
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	isl1a^sa29/sa29
Observed In:	heart heart contraction
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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