FIGURE

Fig. 3

ID

ZDB-FIG-090306-25

Publication

Löhr et al., 2009 - Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages

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Fig. 3

Similar reduction of DA cells in embryos injected with arnt2 or sim1a antisense morpholinos. (A-H) Expression of th at 4 dpf in uninjected wild-type embryos (A,E), arnt2^m1055 mutants (B,F), embryos injected with 2.8 ng arnt2 splice morpholino (C,G) and embryos injected with 1.1 ng sim1a splice morpholino (D,H). (A-D) Affected groups are marked by a bracket. (E-H) Magnification of ventral diencephalic groups 1-6. (A-D) Lateral views; (E-H) dorsal views. Anterior towards the left. Scale bar in H: 100 μm for A-D, 50 μm for E-H. Images in E-H represent z-projections from several adjacent focal planes. AAC, arch associated cluster; LC, locus coeruleus; MO, medulla oblongata; OB, olfactory bulb; PO, preoptic region; Pr, pretectum; PT, posterior tuberculum; SP, subpallium; sym, sympathetic CA neurons; VT, ventral thalamic cluster.

Expression Data

Gene:	th
Fish:	WT arnt2^m1055/m1055 WT + MO2-sim1a WT + MO3-arnt2
Knockdown Reagents:	MO2-sim1a MO3-arnt2
Anatomical Terms:	caudal tuberculum dopaminergic neuron hypothalamus dopaminergic neuron preoptic area dopaminergic neuron pretectum dopaminergic neuron telencephalon dopaminergic neuron
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	arnt2^m1055/m1055 WT + MO2-sim1a WT + MO3-arnt2
Knockdown Reagents:	MO2-sim1a MO3-arnt2
Observed In:	caudal tuberculum dopaminergic neuron dopaminergic neuron differentiation hypothalamus dopaminergic neuron telencephalon dopaminergic neuron
Stage:	Day 4

Phenotype Detail

Acknowledgments

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