FIGURE

Fig. 6

ID

ZDB-FIG-081013-23

Publication

Harris et al., 2008 - Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates

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Fig. 6

Fin development is defective in fls and Nkt mutant zebrafish.

Alizarin red stained adult zebrafish fins show a drastic effect of fls^te370f and Nkt on development of the lepidotrichial dermal rays of both the paired and unpaired fins. A–C,F) Pectoral fins, anterior-dorsal view; D, E) double staining developing pectoral fins with alcian blue and alizarin red show early patterning of the endochondrial bones of the pectoral fin of size matched wild type and Nkt homozygotes (asterisk indicates loss of fourth proximal radial). G) effect of fls and Nkt mutants on the patterning of the pectoral fin skeleton scored as the number of specimens showing alteration in pattern or form over total analyzed. The identity of the proximal radials is noted (I–IV). H–J) Analysis of pelvic fin development in fls and Nkt mutants. Numbers denote anterior-posterior identity of the lepidotrichia. K–M) Defects in the formation of the lepidotrichia in adult anal and (N–P) caudal fin of fls (L and O) and Nkt (M and P). ap, ascending process; cl, cleithrum; co, corticoid; dr, distal radial; sc, scalpula, le, lepidotrichia; pcl, postcleithrum; pr, proximal radial.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eda^{dt1261/dt1261} (TL) edar^{te370f/te370f} (TU)
Observed In:	anal fin distal radial anal fin lepidotrichium anal fin proximal radial caudal fin lepidotrichium lepidotrichium pectoral fin endochondral bone pectoral fin distal radial
Stage:	Adult

Phenotype Detail

Acknowledgments

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