FIGURE

Fig. 1

ID

ZDB-FIG-081010-8

Publication

Gansner et al., 2008 - Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis

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Fig. 1

The pfd^gw1 mutation disrupts notochord and vascular development. A: The notochord (black arrow), caudal vein (white arrow), and fin fold (black arrowheads) form normally in wild-type embryos, and melanin pigmentation is present (white arrowhead). B: pfd^gw1 mutants exhibit notochord kinking (black arrow), a cavernous caudal vein with loss of the usual reticular venous plexus (white arrow), and fin fold attenuation (black arrowheads). Melanin pigmentation is present (white arrowhead). C: Fin fold (arrowheads) and caudal vein (arrow) in a wild-type embryo. D: Attenuated fin fold (arrowheads) and cavernous caudal vein (arrow) typical of pfd^gw1 mutants. E,F: Ventral views of a wild-type embryo (E) and a pfd^gw1 mutant (F) demonstrating skin distention secondary to edema in the mutant (F, arrowheads). Red blood cells have extravasated into the edematous area (F, arrow). All embryos were photographed at 30 hours postfertilization (hpf).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fbn2b^gw1/gw1 (AB)
Observed In:	blood vessel development caudal vein caudal vein plexus median fin fold notochord notochord development trunk trunk integument trunk melanocyte
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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