FIGURE

Fig. 1

ID

ZDB-FIG-080828-32

Publication

Honjo et al., 2008 - Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons

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Fig. 1

erbb3b and erbb2 mutants lack DRG and sympathetic neurons. (A-C) Elavl antibody labeling reveals DRG (arrowheads) and sympathetic neurons (asterisks). DRGs are segmentally arranged, whereas at this stage, sympathetics are not segmental. DRG and sympathetic neurons are present in wild-type embryos (A) but are absent from erbb3b (B) and erbb2 (C) mutants at 7 dpf. (D-F) Elavl-positive enteric neurons appear normal in erbb3b (E) and erbb2 (F) mutants compared with wild-type embryos (D). (G-I) TH antibody labeling reveals sympathetic neurons. Whole-mount labeling of 8 dpf larvae showing that sympathetic neurons (asterisks) are present in wild type (G) but absent from erbb3b (H) and erbb2 (I) mutants. (J-L) Whole-mount labeling of 31 hpf embryos with a neurog1 riboprobe reveals nascent DRG neurons. Nascent DRG neurons (arrowheads) are segmental in wild-type embryos (J) but absent from erbb3b (K) and erbb2 (L) mutants. (M-O) A neurod riboprobe reveals DRG neurons at 36 hpf. DRG neurons (arrowheads) are segmental in wild-type embryos (M) but absent from erbb3b (N) and erbb2 (O) mutants. Lateral views; anterior towards the left. Scale bar: 20 μm.

Expression Data

Genes:	neurod1 neurog1
Antibodies:	Ab1-elavl Ab2-th
Fish:	WT erbb2^st61/st61 erbb3b^st48/st48
Anatomical Terms:	dorsal root ganglion enteric nervous system neuron sympathetic nervous system
Stage Range:	Prim-15 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	erbb2^st61/st61 erbb3b^st48/st48
Observed In:	dorsal root ganglion neuron sympathetic nervous system neuron
Stage Range:	Prim-15 to Days 7-13

Phenotype Detail

Acknowledgments

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