FIGURE

Fig. 1

ID

ZDB-FIG-080730-14

Publication

Clément et al., 2008 - Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher

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Fig. 1

dak^-/- and pic^-/- larvae have similar cartilage morphogenesis phenotypes.

Skeletal preparations of wild-type (A–C), dak^-/- (D–F) and pic^-/- (G–I) at day 6 reveal the shape of the cartilaginous skeleton as well as chondrocyte morphology. Ventral views of the head show that the cartilage elements of dak^-/- and pic^-/- fish are shorter and thicker than wild-type (A,D,G). Dissected cartilage laid flat show a complete lack of chondrocyte flattening and intercalation in skeletal elements from dak^-/- and pic^-/- larvae (B,E,H ceratobranchial 1; C,F,I hyosymplectic). Arrowheads in B and C indicate regions that lack stacking in wild-type embryos. Alcian Blue staining at pH1.0 (HCl 0.1N) does not stain pic^-/- cartilage (G,H,I). Camera lucida drawings of chondrocytes in wild-type and mutant larvae (B′,E′,H′). Scale bars = 50μM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ext2^{to273b/to273b} slc35b2^{to14mx/to14mx}
Observed In:	cartilage development cartilage element chondrocyte
Stage:	Day 6

Phenotype Detail

Acknowledgments

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