FIGURE

Fig. S1

ID

ZDB-FIG-080613-8

Publication

Delporte et al., 2008 - Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors

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Fig. S1

No PBX-PREP-PDX1 complex is observed on homologous pax6a PA1 sequence. When we tested the homologous pax6a PA1 sequence (named PA1a), incubation with nuclear extract led to the formation of four major complexes (arrows, lane 1) which were displaced by adding a 100-fold molar excess of unlabeled PA1a (lane 2). Addition of unlabelled PA1b and somatostatin element UE-A, which bind PBX-PREP-PDX1 and PBX-PREP complex, respectively, do not displace the binding on the probe (lanes 3 and 4). This indicates that the proteins in the pancreatic extract which recognize the two cis-elements PA1b and UE-A do not recognize the homologous pax6a element.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.