FIGURE

Fig. 4

ID

ZDB-FIG-080529-52

Publication

Starr et al., 2004 - Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells

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Fig. 4

Reduction in the number of inner-ear hair cells in mutant larvae. The total number of hair cells was assessed at three developmental times by counting the number of Alexa 488-phalloidin-labeled hair bundles in all sensory epithelia. A reduction in number became noticeable from 60 hpf, as shown here in single confocal sections through WT (A) and mutant (B) posterior maculae. By 120 hpf, many more hair cells had been added to the posterior macula in the WT (C), but little change was observed in the mutant (D), as seen in projections of Z-series through the posterior maculae. In D, arrows show anterior (A) and dorsal (D) directions. (Scale bars: 50 μm.) (E) Similar results were observed when hair cells from all five sensory epithelia in the inner ear were counted at three developmental stages. At least eight larvae were examined for each data point.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848
Observed In:	hair cell posterior macula inner ear hair cell
Stage Range:	Prim-15 to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA