Fig. 6
- ID
- ZDB-FIG-080516-6
- Publication
- Pocock et al., 2008 - Neuronal function of Tbx20 conserved from nematodes to vertebrates
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Rescue of cranial nerve migration defects with C. elegans mab-9 mRNA and cell autonomous function of tbx20 in cranial motor neurons. (A–D) 48 hpf tg(islet1:GFP) zebrafish embryos, dorsal views. (A) Uninjected control; (B) embryo injected with 100 pg mab-9 mRNA; (C) embryo injected with 2 ng tbx20 morpholino; (D) embryo injected with mab-9 mRNA and tbx20 morpholino. A partial rescue of the migration defect of nVII neurons is observed in panel D (black arrows). Quantification of the rescue data is shown in Supplementary Table 2. (E) Diagram illustrating the transplantation procedure (see text for details). (F) Cells loaded with tbx20 morpholino and rhodamine dextran are unable to migrate to rhombomere 6 (right side) unlike their counterparts in the host (left side). |
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Reprinted from Developmental Biology, 317(2), Pocock, R., Mione, M., Hussain, S., Maxwell, S., Pontecorvi, M., Aslam, S., Gerrelli, D., Sowden, J.C., and Woollard, A., Neuronal function of Tbx20 conserved from nematodes to vertebrates, 671-685, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.