FIGURE

Fig. 2

ID

ZDB-FIG-080416-8

Publication

Huang et al., 2008 - Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants

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Fig. 2

Cellular defects of reg6 endothelial cells. (A, B) Overlaid images of bright field and green fluorescent protein (GFP) of wild-type (A) and reg6 (B) 3-dpa regenerating fins showing the leakage of blood cells in reg6 fish (arrows). Transmission electron microscopic images of wild-type fish (C, low magnification; E, high magnification) showing that the blood vessel is enclosed by several endothelial cells which form nice, intact tight junctions (arrow in E). Additional images can be found in Additional file 1. In contrast, the blood vessels in reg6 fish (D) were usually leaking as evidenced by the lack of coverage by endothelial cells (arrow) and the presence of blood cells outside blood vessels (as an endothelial cell is sandwiched by two blood cells in G and arrows in Additional file 2). In addition, reg6 endothelial cells appeared less stretched-out (D), and tight junction were rarely formed among them (F). Scale bars, 2 μm for C, D, F, and G; 10 nm for E. white asterisks, blood cell; black asterisks, endothelial cell.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	reg6^j21/j21; y1Tg
Condition:	physical alteration: anatomical structure
Observed In:	blood cell blood vessel endothelial cell fin fin vasculature
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.