FIGURE

Fig. 1

ID

ZDB-FIG-080326-52

Publication

Berghmans et al., 2005 - tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

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Fig. 1

Induction of apoptosis by γ irradiation is suppressed in tp53 mutant embryos. Embryos were γ irradiated at 24 hpf (16 Gray) and fixed at 30 hpf for TUNEL assay. After the assay of multiple embryos resulting from the intercross of tp53^M214K mutant heterozygous parents, the embryos were genotyped for their tp53 status. Embryos shown are representative of homozygous wild-type (tp53^+/+), heterozygous (tp53^+/M214K), and homozygous mutant (tp53^M214K/M214K) genotypes. White arrows indicate widespread apoptosis in the brain and spinal cord. Embryos were raised at 28°C. All embryos are shown in lateral view with the head to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA