FIGURE

Fig. 5

ID

ZDB-FIG-080107-9

Publication

Grandel et al., 2002 - Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud

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Fig. 5

Dorsal view of pectoral fins on day 5 in (A) a wild-type larva and (B) a nof homozygote after treatment with retinoic acid (10^–9 M, 30% epiboly until 16 hours) and (C) after injection of wild-type raldh2 mRNA on day 6. (D) Injection of nof raldh2 mRNA does not provoke fin development in nof mutants. (E,F) Pectoral fins on d3 are prominent in wild type (E) but do not develop after injecting a raldh2-specific morpholino oligonucleotide (F). hoxb4a expression at 20s in wild-type (G) and (H) nof sibling embryos. (J,L) Similar hoxb4a expression levels as in nof homozygotes are detected upon injection of raldh2-specific morpholino into wild-type embryos (J) and upon injection of 500 pg mRNA derived from the nof-allele of raldh2 into nof homozygotes (L). (I,K) Increase of hoxb4a expression levels upon treatment of nof homozygotes (I) with retinoic acid (10^–9 M; 30% until 20s) and (K) injection of 100 pg of wild-type raldh2 mRNA.

Expression Data

Gene:	hoxb4a
Fish:	WT aldh1a2^u11/u11 WT + MO1-aldh1a2
Knockdown Reagent:	MO1-aldh1a2
Anatomical Term:	hindbrain
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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