FIGURE

Fig. 4

ID

ZDB-FIG-071102-9

Publication

Hadzhiev et al., 2007 - Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish

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Fig. 4

Hedgehog signaling is required for the patterning of the caudal fin. A-C: caudal fin primordium development is blocked in syu^-/-and smu^-/-mutants. A, Wild type embryo tail showing normal embryonic fin fold and melanophore streak (arrowhead) in bright field (left) and GFP fluorescence (right) marking the adult caudal fin primordium (arrow). B, C, In syu^-/-and smu^-/-mutants gfp expression in the fin fold is absent (arrows). The melanophores are abnormally arranged (arrowheads in left). Expression of GFP in the floor plate and residual activity in the notochord is present (arrowhead in B, right). D-I, Hedgehog signaling regulates gene expression in the caudal fin primoridum. Expression of bmp4 (arrows in D, E) and ptc (arrows in F, G) are lost or strongly reduced in smu^-/-. In contrast, the mesenchyme marker msx-C is expressed in the embryonic fin fold in wild type (H, arrow) and in smu^-/-mutants (I, arrow). Lateral views on embryonic tail region of 72 hpf embryos are shown. Scale bar in F indicates 100 μm.

Expression Data

Genes:	bmp4 GFP msx3 ptch2
Fish:	sb15Tg Df(Chr07)t4/t4; sb15Tg smo^b641/b641; sb15Tg
Anatomical Terms:	caudal fin floor plate notochord
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	Df(Chr07)t4/t4; sb15Tg smo^b641/b641; sb15Tg
Observed In:	caudal fin melanocyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.