FIGURE

Fig. 6

ID

ZDB-FIG-070914-67

Publication

Steffen et al., 2007 - The zebrafish runzel muscular dystrophy is linked to the titin gene

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Fig. 6

ruz mutants produce normal sarcomeres but show progressive sarcomeric misalignment. (A–H) Longitudinal sections of skeletal muscle from 3.5 dpf (A–C) or 6.5 dpf (D–H) fish were analyzed by transmission electron microscopy. (A) Wild-type fish at 3.5 dpf show normal sarcomeric organization and alignment. (B, C) ruz mutants contain some normal sarcomeres at 3.5 dpf (B) but are also beginning to show sarcomeric disruption (C). At 6.5 dpf, wild-type fish still display normal sarcomeres (D) while ruz mutants contain only rare regions of ordered myofibrils (E). Instead, myofibers contain collapsed sarcomeres with no apparent organization or alignment (F–H). Arrow indicates fibrils perpendicular to the plane of the section. Arrowheads indicate selected Z-disc structures.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ruz^tk258/tk258 (TL)
Observed In:	skeletal muscle cell myofibril skeletal muscle cell sarcomere skeletal myofibril assembly
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 309(2), Steffen, L.S., Guyon, J.R., Vogel, E.D., Howell, M.H., Zhou, Y., Weber, G.J., Zon, L.I., and Kunkel, L.M., The zebrafish runzel muscular dystrophy is linked to the titin gene, 180-192, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.