FIGURE

Fig. 8

ID

ZDB-FIG-070821-19

Publication

Shimizu et al., 2005 - E-cadherin is required for gastrulation cell movements in zebrafish

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Fig. 8

Cell adhesion between the deep cells and the enveloping layer is disrupted in cdh1 morphant embryos. Wild-type control (wt, A, C, E, G) and cdh1 morphant embryos (MO) embryos (B, D, F, H) were fixed at 8.5 hpf (80% epiboly for the wild-type) and subjected to electron microscopic analysis. Lateral regions. Adhesion between the enveloping layer (EVL) and the deep cells (DCs) was detected in the wild-type control embryos (indicated by arrows in A, C, E), but was severely affected in the cdh1 morphant embryos (arrows in B, D, F). In contrast, the adhesions between the EVL cells (arrowheads in A, C, D) or between the DCs (arrowheads in G, H) were not significantly affected in the cdh1 morphant embryos, compared with the wild-type control embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO6-cdh1
Knockdown Reagent:	MO6-cdh1
Observed In:	cell-cell adhesion involved in gastrulation DEL EVL
Stage:	75%-epiboly

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 122(6), Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., and Hibi, M., E-cadherin is required for gastrulation cell movements in zebrafish, 747-763, Copyright (2005) with permission from Elsevier. Full text @ Mech. Dev.