FIGURE

Fig. 6

ID

ZDB-FIG-070801-15

Publication

Jin et al., 2007 - A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos

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Fig. 6

intersection regulates vascular patterning. (A–D) Lateral bright-field and epifluorescent micrographs of 32 hpf embryos. Vascular patterning defects can be observed by visualizing Tg(flk1:EGFP)^s843 expression, but not via bright-field microscopy. int^s413 mutants fail to connect the lateral dorsal aortae (LDA) to form the dorsal aorta (DA), and the anterior and posterior cardinal veins (ACV and PCV) to the common cardinal vein (CCV). (E–H) Dorsal views of ve-cadherin and Tg(flk1:EGFP)^s843 expression. int^s413 mutant embryos exhibit a pronounced dilation of the PCV (inset in panel D).

Expression Data

Gene:	cdh5
Fish:	TL int^s413/s413 (TL)
Anatomical Terms:	anterior cardinal vein common cardinal vein dorsal aorta lateral dorsal aorta posterior cardinal vein
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	int^s413/s413; s843Tg
Observed In:	anterior cardinal vein blood vessel morphogenesis caudal vein plexus common cardinal vein lateral dorsal aorta posterior cardinal vein
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 307(1), Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y., A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos, 29-42, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.