FIGURE

Fig. 1

ID

ZDB-FIG-070619-8

Publication

Shu et al., 2007 - Na,K-ATPase α2 and Ncx4a regulate zebrafish left-right patterning

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Fig. 1

Na,K-ATPase α2 is required for heart and gut LR patterning in zebrafish. (A-D) Live 2-day-old control (A), α2 morphant (B), Ncx4a morphant (C) and A23187-treated (D) embryos. (E-G) α2 morphants that exhibited normal (E), absent (F) or reversed (G) cardiac looping after 2 days of development. Ventral view, with anterior to the top. v, ventricle; a, atrium. (H-J) 2-day-old α2 morphants with normal (H), straight (I) or reversed (J) positions of gut, liver and pancreas. Dorsal view, with anterior to the top. li, liver; p, pancreas. (K) Bar chart detailing the heart and gut laterality phenotypes of uninjected embryos and those injected with CTL-MO, α2-MO, α2-SP-MO, Ncx4a-MO and Ncx4a-SP-MO. The effects of α2-SP-MO and Ncx4a-SP-MO on RNA processing are shown in the upper and lower panels, respectively, on the right.

Expression Data

Genes:	foxa3 myl7
Fish:	TL TL + MO1-atp1a2a
Knockdown Reagent:	MO1-atp1a2a
Anatomical Terms:	gut heart liver pancreas
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO1-atp1a2a TL + MO1-slc8a4a TL + MO2-atp1a2a TL + MO2-slc8a4a
Knockdown Reagents:	MO1-atp1a2a MO1-slc8a4a MO2-atp1a2a MO2-slc8a4a
Observed In:	determination of left/right symmetry digestive tract development embryonic heart tube development gut heart heart looping liver liver development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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