FIGURE

Fig. 6

ID

ZDB-FIG-070307-26

Publication

Nyholm et al., 2007 - The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum

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Fig. 6

Multiple Tcf/Lefs are required for zic gene expression. Embryos injected with the MOs shown at the lower left of each panel and stained for zic2aD5:gfp (A,C,E,G,I) or zic2a (B,D,F,H,J) at 18 hpf. (C-D) Strongly affected tcf3 morphants had anterior trunctions and reduced zic2aD5:gfp (asterisks) and zic2a domains. (E-J) lef1 morphants showed a strong reduction in zic2aD5:gfp (E) and a mild reduction in zic2a (F). tcf7 morphants showed a mild reduction in zic2aD5:gfp (G), but normal zic2a (H). lef1+tcf7 morphants showed a strong reduction in zic2aD5:gfp (I) and mild reduction in zic2a (J). All views are lateral, anterior to the left. Arrowheads indicate the midbrain.

Expression Data

Gene:	zic2a
Fish:	WT WT + MO1-tcf7 WT + MO2-lef1 WT + MO1-tcf7 + MO2-lef1 WT + MO1-tcf7l1b + MO2-tcf7l1a
Knockdown Reagents:	MO1-tcf7 MO1-tcf7l1b MO2-lef1 MO2-tcf7l1a
Anatomical Terms:	diencephalon hindbrain midbrain neural tube optic stalk telencephalon
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-tcf7 WT + MO2-lef1 WT + MO1-tcf7l1b + MO2-tcf7l1a
Knockdown Reagents:	MO1-tcf7 MO1-tcf7l1b MO2-lef1 MO2-tcf7l1a
Observed In:	brain forebrain midbrain
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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