FIGURE

Fig. 6

ID

ZDB-FIG-070306-11

Publication

Jopling et al., 2007 - Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation

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Fig. 6

Csk acts upstream of Fyn and Yes in gastrulation cell movements. The Csk-MO (5 ng) was injected alone or together with human csk mRNA (150 pg) or low levels of Fyn/Yes-MO (0.125 ng each, low). As a control, high levels of Fyn- and Yes-MOs that induce CE defects were injected (5 ng each, high). The angle between the most anterior and posterior embryonic structure was determined at the 1-somite stage in at least 20 embryos and the average angle is depicted here in degrees. Two tailed student t-tests indicate a significant increase in the angle after injection of Csk-MO alone (P < 0.001, single asterisk) and a significant decrease in the angle after co-injection of csk mRNA or Fyn/Yes-MO (P < 0.001, double asterisk).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-csk
Knockdown Reagent:	MO1-csk
Observed In:	cell migration involved in gastrulation
Stage:	1-4 somites

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(2), Jopling, C., and den Hertog, J., Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation, 129-136, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.