FIGURE

Fig. 5

ID

ZDB-FIG-070102-5

Publication

Gregg et al., 2003 - Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation

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Fig. 5

Analysis of additional chromatin remodeling mutants reveals specificity for function in retinal development. (a–c) Transverse sections through the central retina of WT (a), baf53 mutant hi550 (b), and snf2h mutant hi1072 (c). Baf53, which has been shown to complex with Brg1, has a retinal lamination phenotype similar to yng when mutated. snf2h, which encodes the ATPase for ISWI-type chromatin remodeling complexes, shows normal retinal differentiation. (d) Summary model: Ath5 and Hedgehog (Hh) are required for retinal cell type specification, whereas the Brahma complex is required for MAP kinase activation, which is necessary for retinal differentiation and morphogenesis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	actl6a^{hi1072Tg/hi1072Tg} smarca5^{hi550Tg/hi550Tg}
Observed In:	retina layer formation
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA