FIGURE

Fig. 3

ID

ZDB-FIG-061104-11

Publication

Lucas et al., 2006 - The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons

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Fig. 3

dbh and th expression in 4 dpf cervical sympathetic ganglia of wild type and hands off mutants. Whole-mount in situ hybridizations for dbh (A,B) and th (C,D) as in Fig. 2. dbh and th label sympathetic ganglia. In addition, in the caudal region of the CSG a cluster of more ventrally located chromaffin cells with more intensive staining becomes apparent at 4 dpf (arrowheads). hands off embryos show only very few dbh⁺ (C) and th⁺ cells (D), demonstrating that noradrenergic differentiation is prevented in 4 dpf CSG neurons and chromaffin cells. (E) Area of total dbh- and th-expressing cells in hands off mutants compared with wild type. Data are presented as mean ± s.e.m. (Number of embryos analysed: 14 wild type, six mutant for dbh; 12 wild type, seven mutant for th.) (^***P<0.001.)

Expression Data

Genes:	dbh th
Fish:	WT Df(Chr01:hand2)s6/s6
Anatomical Terms:	chromaffin cell superior cervical ganglion
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	Df(Chr01:hand2)s6/s6
Observed In:	noradrenergic neuron differentiation superior cervical ganglion sympathetic ganglion development
Stage:	Day 4

Phenotype Detail

Acknowledgments

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