FIGURE

Fig. 4

ID

ZDB-FIG-060410-4

Publication

Jadrich et al., 2006 - The TGFβ activated kinase TAK1 regulates vascular development in vivo

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Fig. 4

The yolk sac vasculature of the Tak1{Delta}/{Delta} embryos fails to undergo angiogenesis. (A,B) E9.5 yolk sacs of Tak1+/{Delta} and Tak1{Delta}/{Delta} embryos, respectively. The yolk sac vascular plexus in A has undergone angiogenesis to create a branched network of mature vitelline vessels (arrowhead). The yolk sac vascular plexus in B has not remodeled but has retained its honeycomb-like structure of blood islands (arrowhead). The vessels in B are also prone to rupture, causing pooling of blood in the yolk sac (arrow). (C,D) Cross-sections of Tak1+/{Delta} and Tak1{Delta}/{Delta} yolk sacs, respectively, that are immunostained for vSMCs with an antibody to SMA (brown). The Tak1+/{Delta} yolk sac in C contains a mature vitelline vessel surrounded by a layer of smooth muscle (arrowhead). The Tak1{Delta}/{Delta} yolk sac in D has no mature vitelline vessels, the existing vessels are extremely dilated and have little SMA expression.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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