Fig. 7
Expression of the upstream gene, neurogenin1, for HuC, tlx3a, and neuroD marking RB neurons and neurons in the trigeminal placodes, in embryos injected with dlx3b-MO and dlx4b-MO at 3-somite stage. (A and C) Wild-type embryos. (B and D) 20 ng ATG-dlx3b-MO/20 ng ATG-dlx4b-MO-injected embryos. (A and B) The expression of neurogenin1 in RB neuron precursors (rb) is normal in MO-injected embryos. Dorsal views. (C and D) The expression of neurogenin1 in the precursors of neurons in the trigeminal placodes (tg) is absent in MOs-injected embryos (D). Anterior views. mn, primary motor neuron precursors; in, primary interneuron precursors; mi, anterior medial hindbrain interneuron precursors; li, anterior lateral hindbrain interneuron precursors. |
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Stage: | 1-4 somites |
Reprinted from Developmental Biology, 276(2), Kaji, T., and Artinger, K.B., dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula, 523-540, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.