CRISPR

CRISPR1-pparg

ID
ZDB-CRISPR-211116-4
Name
CRISPR1-pparg
Previous Names
None
Target
Sequence
5' - GGGCTTCGGCCTGAGCGCTC - 3'
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
None
Genome Resources
None
Target Location
Constructs
No data available
Genomic Features
Genomic Feature Affected Genomic Regions
ecn6 pparg
Expression
Gene expression in Wild Types + CRISPR1-pparg
No data available
Phenotype
Phenotype resulting from CRISPR1-pparg
No data available
Phenotype of all Fish created by or utilizing CRISPR1-pparg
Phenotype Fish Conditions Figures
liver triglyceride decreased amount, exacerbated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
liver fatty acid amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
liver reactive oxygen species amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism antioxidant activity increased process quality, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism ddit3 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
male organism liver Ab4-pparg labeling decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
male organism decreased life span, abnormal ppargecn6/ecn6 (AB) chemical treatment by environment: ammonium chloride Fig. 2 from Wang et al., 2022
female organism pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
liver triglyceride decreased amount, abnormal ppargecn6/ecn6 (AB) control Fig. 2,  Fig. 5,  Fig. 6 from Wang et al., 2022
male organism pleuroperitoneal region pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism liver composition, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism nfe2l2a expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 6 from Wang et al., 2022
female organism il1b expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism aerobic respiration decreased rate, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 2 from Wang et al., 2022
female organism pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism casp3a expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism atf6 expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism pnpla2 expression increased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
male organism liver pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism ddit3 expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism bcl2a expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
male organism pleuroperitoneal region Ab4-pparg labeling decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism atf6 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
liver malonaldehyde amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism cat expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 6 from Wang et al., 2022
female organism life span, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine, heat exposure Fig. 6 from Wang et al., 2022
female organism acaca expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism nfkb2 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism ddit3 expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism gpx1a expression increased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism hspa5 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism sod1 expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3 from Wang et al., 2022
male organism testis pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism bcl2a expression increased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism liver Ab4-pparg labeling decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism decreased life span, abnormal ppargecn6/ecn6 (AB) cold exposure Fig. 2,  Fig. 5,  Fig. 6 from Wang et al., 2022
liver triglyceride decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
liver fatty acid increased amount, abnormal ppargecn6/ecn6 (AB) control Fig. 5,  Fig. 6 from Wang et al., 2022
whole organism decreased weight, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism ovary pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism reactive oxygen species increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3 from Wang et al., 2022
whole organism decreased weight, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 2 from Wang et al., 2022
female organism tnfa expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism dgat2 expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
female organism nfkb2 expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 5,  Fig. 6 from Wang et al., 2022
female organism life span, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine, chemical treatment by environment: ammonium chloride Fig. 5 from Wang et al., 2022
female organism pleuroperitoneal region pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism acaca expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
female organism life span, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine, heat exposure Fig. 5 from Wang et al., 2022
female organism liver composition, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism cpt1aa expression increased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
liver antioxidant activity increased process quality, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism decreased life span, abnormal ppargecn6/ecn6 (AB) chemical treatment by environment: ammonium chloride Fig. 2,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism liver composition, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism gpx1a expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
female organism lipase activity increased occurrence, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 2 from Wang et al., 2022
male organism muscle pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism life span, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine, cold exposure Fig. 6 from Wang et al., 2022
visceral fat decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism casp9 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
female organism bcl2a expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism hspa5 expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism nfe2l2a expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism triglyceride decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 2 from Wang et al., 2022
liver malonaldehyde increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism superoxide dismutase activity decreased occurrence, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3 from Wang et al., 2022
female organism visceral fat decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism cat expression increased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism decreased life span, abnormal ppargecn6/ecn6 (AB) heat exposure Fig. 2,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism il1b expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
female organism casp9 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
male organism intestine pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism casp9 expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 5,  Fig. 6 from Wang et al., 2022
female organism il1b expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism fatty acid increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 2 from Wang et al., 2022
liver malonaldehyde amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
liver reactive oxygen species increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3,  Fig. 6 from Wang et al., 2022
female organism dgat2 expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism muscle pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism fasn expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism nfkb2 expression increased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
liver fatty acid amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism cholesterol decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 2 from Wang et al., 2022
female organism life span, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine, chemical treatment by environment: ammonium chloride Fig. 6 from Wang et al., 2022
female organism pnpla2 expression increased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
female organism intestine pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism liver pparg expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism atf6 expression decreased amount, abnormal ppargecn6/ecn6 (AB) chemical treatment by diet: (R)-carnitine Fig. 6 from Wang et al., 2022
female organism life span, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine, cold exposure Fig. 5 from Wang et al., 2022
liver superoxide dismutase activity decreased occurrence, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 3 from Wang et al., 2022
female organism pleuroperitoneal region Ab4-pparg labeling decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 1 from Wang et al., 2022
female organism decreased weight, abnormal ppargecn6/ecn6 (AB) control Fig. 5 from Wang et al., 2022
female organism fasn expression decreased amount, abnormal ppargecn6/ecn6 (AB) standard conditions Fig. 6 from Wang et al., 2022
female organism hspa5 expression amount, ameliorated ppargecn6/ecn6 (AB) chemical treatment by diet: N-acetyl-L-cysteine Fig. 5 from Wang et al., 2022
Citations
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