Gene
pparg
- ID
- ZDB-GENE-990415-213
- Name
- peroxisome proliferator-activated receptor gamma
- Symbol
- pparg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Acts upstream of or within regulation of lipid metabolic process and triglyceride homeostasis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 81 figures from 63 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017619 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial partial lipodystrophy type 3 | Alliance | Lipodystrophy, familial partial, type 3 | 604367 |
| obesity | Alliance | Obesity, severe | 601665 |
| type 2 diabetes mellitus | Alliance | Insulin resistance, severe, digenic | 125853 |
| type 2 diabetes mellitus | Alliance | {Diabetes, type 2} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR022590 | Peroxisome proliferator-activated receptor gamma, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003074 | Peroxisome proliferator-activated receptor |
| Family | IPR003077 | Peroxisome proliferator-activated receptor gamma |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma | Peroxisome proliferator-activated receptor gamma, N-terminal | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A6XMH6
|
527 |
Interactions and Pathways
Plasmids