CRISPR

CRISPR3-scn1lab

ID

ZDB-CRISPR-200818-1

Name

CRISPR3-scn1lab

Previous Names

None

Target

scn1lab (1)

Sequence

5' - GATTGGTTGGCAGGTTGCCG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zu1	scn1lab

Expression

Gene expression in Wild Types + CRISPR3-scn1lab

No data available

Phenotype

Phenotype resulting from CRISPR3-scn1lab

No data available

Phenotype of all Fish created by or utilizing CRISPR3-scn1lab

Phenotype	Fish	Conditions	Figures
swimming magnitude, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: fenfluramine	Fig 3 from Weuring et al., 2020
brain neuronal action potential increased frequency, abnormal	scn1lab^zu1/zu1	standard conditions	Fig 2 , Fig 5 from Weuring et al., 2020
swimming magnitude, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: sodium channel modulator	Fig 4 from Weuring et al., 2020
swim bladder uninflated, abnormal	scn1lab^zu1/zu1	standard conditions	Fig 1 from Weuring et al., 2020
swimming magnitude, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: sodium channel modulator	Fig 4 from Weuring et al., 2020
swimming increased magnitude, abnormal	scn1lab^zu1/zu1	chemical treatment by environment: carbamazepine	Fig 3 from Weuring et al., 2020
swimming increased magnitude, abnormal	scn1lab^zu1/zu1	chemical treatment by environment: veratridine	Fig 4 from Weuring et al., 2020
brain neuronal action potential frequency, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: fenfluramine	Fig 5 from Weuring et al., 2020
pigment accumulation increased occurrence, abnormal	scn1lab^zu1/zu1	standard conditions	Fig 1 from Weuring et al., 2020
swimming magnitude, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: GABA modulator	Fig 3 from Weuring et al., 2020
brain neuronal action potential frequency, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: sodium channel modulator	Fig 5 from Weuring et al., 2020
swimming increased magnitude, exacerbated	scn1lab^zu1/zu1	chemical treatment by environment: pentetrazol	Fig 2 from Weuring et al., 2020
brain neuronal action potential frequency, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: sodium channel modulator	Fig 5 from Weuring et al., 2020
swimming magnitude, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: sodium channel modulator	Fig 4 from Weuring et al., 2020
whole organism gamma-aminobutyric acid decreased amount, abnormal	scn1lab^zu1/zu1	standard conditions	Fig 2 from Weuring et al., 2020
swimming increased magnitude, abnormal	scn1lab^zu1/zu1	chemical treatment by environment: clemizole	Fig 3 from Weuring et al., 2020
swimming increased magnitude, abnormal	scn1lab^zu1/zu1	standard conditions	Fig 2 , Fig 3 , Fig 4 from Weuring et al., 2020
swimming magnitude, ameliorated	scn1lab^zu1/zu1	chemical treatment by environment: valproic acid	Fig 3 from Weuring et al., 2020
swimming increased magnitude, abnormal	scn1lab^zu1/zu1	chemical treatment by environment: phenytoin	Fig 3 from Weuring et al., 2020
swimming increased magnitude, exacerbated	scn1lab^zu1/+	chemical treatment by environment: pentetrazol	Fig 2 from Weuring et al., 2020

Citations