FIGURE SUMMARY
Title

Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo

Authors
Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C.
Source
Full text @ Development
Fig. 1

Mutations affecting heart size. (A,B) wild type; (C,D) enlarged heart of vtnm201; (E,F) small heart of hasm129. No chamber organization is evident in hasm129. A, C and E are Nomarski views of living embryos and B, D and F are histological sections. The atrium is in focus in A and C and in the histological section of D. a, atrium, v, ventricle. Scale bar, 100 µm.
Fig. 2

The mutant panm313 has a reduced ventricle, as shown here at 48 hpf. (A) Nomarski view of the living embryo. (B) Histological section. The atrium appears to connect directly to the bulbus arteriosus. Scale bar, 100 µm.
Fig. 3

Two separate hearts are formed in the cardia bifida mutations. (A) wild type, ventral view; (B) milm93, ventral view; (C) milm93, histological section; all at 36 hpf. The two hearts (arrows, although one is slightly out of focus) are visible in whole embryos (B) as well as in cross sections (C). Endocardium not shown in these sections. Scale bars, 250 µm for A and B; 100 µm for C.

PHENOTYPE:
Fish:
Observed In:
Stage: Prim-25
Fig. 4

Mutations that perturb the development of the atrioventricular valves. (A,C) Wildtype sibling embryos, corresponding to (B) jekm310 and (D) m27. The atrioventricular valves are clearly visible at 96 hpf of development in the wild type. Both mutants lack those structures. a, atrium; v, ventricle. Scale bar, 100 µm.
Fig. 5

Hemorrhage mutants. Extravasation of blood in the head (arrows) in (A) bbhm292 and (B) m413. Scale bar, 250 µm.
Fig. 6

The effect of some mutations that affect heart function. (A) Atrial view of weam448, at 48 hpf. The atrium is silent and there is expansion of the cardiac jelly (arrowheads). (B) Atrial view of halm235, at 48 hpf. The ventricle is weak and the atrium is enlarged. (C) pplm340, at 48 hpf. Both chambers are dysmorphic. Scale bar, 100 µm.
Table 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Table 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:
Fish:
Observed In:
Stage: Long-pec
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Unillustrated author statements

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development
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