FIGURE SUMMARY
Title

FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity

Authors
Oh, C.K., Ko, Y., Park, J.J., Heo, H.J., Kang, J., Kwon, E.J., Kang, J.W., Lee, Y., Myung, K., Kang, J.M., Ko, D.S., Kim, Y.H.
Source
Full text @ Biosci. Rep.
Figure 1

Flow charts of study design

(A) Up-regulated transcripts were 0 from GSE57691 and 284 from GSE7084. Down-regulated transcripts were 438 from 57691 and 208 from GSE7084. Twelve genes were significant in both cohorts. (B) Of these 12 genes, 3 were significant between intermediate size of AAA and large size of AAA in GSE 98278; 2 were significant between stable AAA and rupture AAA in GSE 98278. FRZB and C1orf24 were concomitantly significant. Abbreviations: eAAA, elective AAA; iAAA, intermediate AAA; lAAA, large AAA; rAAA, ruptured AAA.
Figure 2

Box plots for the expression values of <italic>FRZB</italic> and <italic>C1orf24</italic>

(A) The expression values of between FRZB and C1orf24 between AAA patients (n=49) and non-AAA patients (n=10) from GSE 57691. FRZB and C1orf24 were significantly down-expressed in AAA patients. (B) The expression values of FRZB and C1orf24 between AAA patients (n=10) and non-AAA patients (n=11) from GSE 7084. FRZB and C1orf24 were significantly down-expressed in AAA patients. (C) The expression values of FRZB and C1orf24 between intermediate size AAA (n=15) and large size AAA (n=16) from GSE 98278. FRZB and C1orf24 were significantly down-expressed in large size AAA. (D) The expression values of FRZB and C1orf24 between eAAA (n=31) and rAAA (n=17) from GSE 98278. FRZB and C1orf24 were significantly down-expressed in ruptured AAA. Abbreviations: eAAA, elective AAA; iAAA, intermediate AAA; lAAA, large AAA; rAAA, ruptured AAA.
Figure 3

<italic>frzb</italic> is essential for the development of zebrafish embryo through regulation of vascular integrity

(A) Imaging of live embryos after morpholino injection (0, 2.5, 5, and 10 ng). (B) Confocal imaging of fli1; DsRed transgenic zebrafish embryos from control embryos and frzb ATG MO-injected embryos. Abbreviations: AV, axial vein; DA, dorsal aorta; hollow arrow, narrow dorsal aorta and axial vein; ISV, intersomite vessel. White arrow, abnormal branch of intersomite vessel.
Acknowledgments
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