- Title
-
Role of oxidative stress in clofazimine-induced cardiac dysfunction in a zebrafish model
- Authors
- Ng, P.C.I., Chan, J.Y.W., Leung, R.K.K., Li, J., Ren, Z., Chan, A.W.H., Xu, Y., Lee, S.S., Wang, R., Ji, X., Zheng, J., Chan, D.P.C., Yew, W.W., Lee, S.M.Y.
- Source
- Full text @ Biomed. Pharmacother.
Fig. 1. Cardiac functions of zebrafish (2 dpf) exposed to various concentrations of CFZ for 2 days by (A) heart rate; (B) stroke volume; (C) cardiac output; and (D) percentage of fractional shortening. Data are presented as mean ± S.D. *P < 0.05 significantly different compared with the control group. PHENOTYPE:
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Fig. 2. Representative phenotypic images of pericardial effusion and blood accumulation of 4 dpf zebrafish larvae treated with 4 mg/L of CFZ for 2 days (B), compared with the control (A). Black arrow denotes the pericardial effusion while white arrow denotes the blood accumulation in the heart. PHENOTYPE:
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Fig. 3. Cardiac functions of zebrafish (2 dpf) measured after 2 days of co-treatment with CFZ (4 mg/L) and various concentrations of NAC (10, 50, 100 μM) by (A) heart rate; (B) stroke volume; (C) cardiac output; and (D) percentage fractional shortening. Data are presented as mean ± S.D. *P < 0.05, **P < 0.01 significantly different compared with the control group. PHENOTYPE:
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Fig. 4. Effects of CFZ on SOD levels in zebrafish larvae. 2dpf zebrafish larvae were treated with CFZ (1, 2, 4 mg/L respectively) or vehicle (Ctrl) for 2days. Data are presented as mean ± S.D. *P < 0.05 significantly different compared with the control group. PHENOTYPE:
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