ZFIN All Figures, Sourbron <i>et al.</i>, 2017

Fig. 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	TL scn1lab^s552/s552 (TL)
Conditions:	chemical treatment by environment: 1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide chemical treatment by environment: 4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile.HCl chemical treatment by environment: 1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine chemical treatment by environment: ICI 118551 chemical treatment by environment: N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine hydrochloride chemical treatment by environment: 1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide chemical treatment by environment: 2-(4-chlorophenoxy)butanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester
Observed In:	locomotory behavior
Stage:	Days 7-13

Phenotype details

Fig. 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	scn1lab^s552/s552 (TL)
Conditions:	chemical treatment by environment: 1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide chemical treatment by environment: 4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile.HCl chemical treatment by environment: 1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine chemical treatment by environment: ICI 118551 chemical treatment by environment: N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine hydrochloride chemical treatment by environment: 1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide chemical treatment by environment: 2-(4-chlorophenoxy)butanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester
Observed In:	regulation of action potential firing pattern
Stage:	Days 7-13

Phenotype details

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	TL scn1lab^s552/s552 (TL)
Conditions:	chemical treatment by environment: fenfluramine chemical treatment by environment: LY-310762 hydrochloride chemical treatment by environment: ketanserin chemical treatment by environment: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea chemical treatment by environment: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride chemical treatment by environment: fenfluramine chemical treatment by environment: fenfluramine
Observed In:	locomotory behavior
Stage:	Days 7-13

Phenotype details

Fig. 5

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	scn1lab^s552/s552 (TL)
Conditions:	chemical treatment by environment: fenfluramine chemical treatment by environment: LY-310762 hydrochloride chemical treatment by environment: ketanserin chemical treatment by environment: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea chemical treatment by environment: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride chemical treatment by environment: fenfluramine chemical treatment by environment: fenfluramine
Observed In:	regulation of action potential firing pattern
Stage:	Days 7-13

Phenotype details

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	TL scn1lab^s552/s552 (TL)
Conditions:	chemical treatment by environment: LY-310762 hydrochloride chemical treatment by environment: ketanserin chemical treatment by environment: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea chemical treatment by environment: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride chemical treatment by environment: 1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester
Observed In:	locomotory behavior
Stage:	Days 7-13

Phenotype details

Fig. 7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	TL scn1lab^s552/s552 (TL)
Condition:	chemical treatment by environment: fenfluramine
Observed In:	head dopamine head gamma-aminobutyric acid head glutamic acid head NAD head serotonin
Stage:	Days 7-13

Phenotype details

Acknowledgments

Full text @ Front Pharmacol

Sourbron et al., 2017

ZDB-PUB-170422-8
PMID:28428755

Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish.

Sourbron et al., 2017 ZDB-PUB-170422-8 PMID:28428755

Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish.

Sourbron et al., 2017

ZDB-PUB-170422-8
PMID:28428755