Electrographic seizure recording and seizure score algorithm.

(a) An electroencephalograph recorded from a surface electrode contacted to a zebrafish head. A zoomed electrograph was shown for the instance noted as ②. (b) Corresponding time-derivative of electrograph in (a). A zoomed time-derivate was shown for the instance ②. (c) Cross-correlation between time-derivatives of spatially distributed five electrode signals. The seizure score is a summation of the off-diagonal numbers of the cross-correlation set and can effectively screen out non-seizure-like electrographic signals like ①. (d) Representative EEG episodes of a PTZ-induced epilepsy model showing ictal- and interictal-like bursts. The red line is averaged from nearby 10 data point attached as 1 kHz. (e) Seizure score vs. time plot for the PTZ-induced epilepsy model. Time spans for the representative EEG episodes are indicated as Roman numerals. (f) Corresponding EEG spectra vs. time.

Distinguishing epileptic artifacts in iZAP.

(a) Various electrophysiology modalities detectable in iZAP system. The current iZAP system can distinguish seizure-like EEG signals from (b) eye and (c) tail (i.e., electrooculography and electromyography). The corresponding videographs were taken as 30 frames per second.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.