Lab

Scholpp Lab

Lab ID
ZDB-LAB-080129-1
PI / Directory
Scholpp, Steffen
Contact Person
Scholpp, Steffen
Email
s.scholpp@exeter.ac.uk
URL
http://biosciences.exeter.ac.uk/staff/index.php?web_id=Steffen_Scholpp
Address
Living System Institute University of Exeter Exeter, UK EX4 4QD
Country
United Kingdom
Phone
Fax
Line Designation
uex
Genomic Features
Statement of Research Interest
Wnt signalling is one of the most important signalling networks in development and homeostasis. Wnt malfunction is implicated in various forms of disease, including cancer and degenerative diseases. Activation of this signalling networks relies on proper dissemination of Wnt proteins in a tissue. Albeit 30 years of Wnt research, we still do not understand how the distribution of signalling molecules is controlled. However, this knowledge is important because it will open up completely new strategies to control Wnt signalling in development, regeneration and diseases by altering its transport route. Using zebrafish embryos, we have shown that extracellular Wnt trafficking requires signalling filopodia known as cytonemes. We want to understand the molecular mechanism controlling cytoneme emergence to allow Wnt proteins transport through a vertebrate tissue over hundreds of micrometers and to establish an effective signalling gradient.
Lab Members
Brunt, Lucy Post-Doc Ono, Yosuke Post-Doc Bamsey, Jessica Graduate Student
Cooper, Emma Graduate Student Dawes, Michael Graduate Student Fang, Kevin Graduate Student
Sutton, Gemma Graduate Student Bhandari, Ashish Technical Staff Sanders, Kelly Technical Staff
Zebrafish Publications of lab members