ZFIN Phenotype Statement: thymus pro-T cell lck expression decreased amount, abnormal

Phenotype:	thymus pro-T cell lck expression decreased amount, abnormal
Note:	This phenotype statement describes a gene expression or antibody labeling pattern. Anatomy terms are combined with a gene or antibody and phenotype quality.

EXPRESSION ANATOMY:

Name:	thymus
Synonyms:
Definition:	Paired organ where maturation of T-lymphocytes occurs. The adult thymus located on the dorsomedial aspect of the branchial cavity above the third pharyngeal cartilage. The thymus undergoes a period of rapid growth beginning at about the third week and continuing for several more weeks. Accompanying this growth is a dramatic change in the shape of the thymus. It is ovoid initially and then starts to grow dorsally along the skull, forming a characteristic protrusion. During this growth period the adult pattern of rag1-positive cortex and rag1-negative medulla becomes established. The protrusions diminish with age and the thymus gradually shrinks; at two years, the thymus is again confined to the pharynx with minimal if any protrusion.
Ontology:	Anatomy Ontology [ZFA:0001078]

Name:	pro-T cell
Synonyms:	DN1 cell, DN1 thymocyte, pro-T lymphocyte, TN1 cell
Definition:	A progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.
Ontology:	Anatomy Ontology [ZFA:0009350]

EXPRESSED GENE:

Symbol:

Name:

LCK proto-oncogene, Src family tyrosine kinase

Previous Name:

zgc:136695

Location:

Chr: 17 Mapping Details/Browsers

EXPRESSION QUALITY:

Name:	decreased amount
Synonyms:	decreased, decreased number, present in fewer numbers in organism, reduced, subnumerary
Definition:	An amount which is relatively low.
Ontology:	Phenotypic Quality Ontology [PATO:0001997]