| Phenotype: | whole organism hypoxia-inducible factor-1alpha signaling pathway decreased efficacy, exacerbated |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | whole organism |
|---|---|
| Synonyms: | multi-cellular organism |
| Definition: | Anatomical structure that is an individual member of Danio rerio. |
| Ontology: | Anatomy Ontology [ZFA:0001094] |
| Name: | hypoxia-inducible factor-1alpha signaling pathway |
|---|---|
| Synonyms: | HIF1alpha pathway, hypoxia-inducible factor signaling, hypoxia-inducible factor-1alpha signalling pathway |
| Definition: | The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. |
| Ontology: | GO: Biological Process [GO:0097411] QuickGO AmiGO |
| Name: | decreased efficacy |
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| Synonyms: | |
| Definition: | A decrease in the ability of a process to produce its output. |
| Ontology: | Phenotypic Quality Ontology [PATO:0015003] |
| Tag: | exacerbated |
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| Definition: | This annotation denotes a significantly exaggerated phenotype resulting from an additional reagent or mutation. |