| Phenotype: | retinal cone cell cytoskeleton of presynaptic active zone detached from retinal outer plexiform layer postsynaptic density, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | retinal cone cell |
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| Synonyms: | retinal cone cells |
| Definition: | One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. |
| Ontology: | Anatomy Ontology [ZFA:0009262] |
| Name: | cytoskeleton of presynaptic active zone |
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| Synonyms: | active zone cytomatrix, CAZ, pre-synaptic cytoskeletal matrix assembled at active zones, pre-synaptic dense body, pre-synaptic ribbon, presynaptic cytomatrix assembled at active zones, presynaptic cytoskeletal matrix, presynaptic cytoskeletal matrix assembled at active zones, presynaptic dense body, presynaptic ribbon, ribbon, synaptic ribbon, T-bar, T-bar ribbon |
| Definition: | The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites. |
| Ontology: | GO: Cellular Component [GO:0048788] QuickGO AmiGO |
| Name: | detached from |
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| Synonyms: | detached |
| Definition: | An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity. |
| Ontology: | Phenotypic Quality Ontology [PATO:0001453] |
| Name: | retinal outer plexiform layer |
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| Synonyms: | retinal outer plexiform layers |
| Definition: | The layer within the retina where the bipolar cells synapse with the photoreceptor cells. |
| Ontology: | Anatomy Ontology [ZFA:0001330] |
| Name: | postsynaptic density |
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| Synonyms: | neuronal postsynaptic density, post synaptic density, post-synaptic density, postsynaptic density of dendrite |
| Definition: | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| Ontology: | GO: Cellular Component [GO:0014069] QuickGO AmiGO |