Phenotype: | pyroptotic inflammatory response increased occurrence, ameliorated |
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Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
Name: | pyroptotic inflammatory response |
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Synonyms: | pyroptosis |
Definition: | A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death. |
Ontology: | GO: Biological Process [GO:0070269] QuickGO AmiGO |
Name: | increased occurrence |
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Synonyms: | increased incidence |
Definition: | An occurrence which is relatively high. |
Ontology: | Phenotypic Quality Ontology [PATO:0002051] |
Tag: | ameliorated |
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Definition: | This annotation denotes a significantly rescued phenotype resulting from an additional reagent or mutation. |