U2_snRNA

Term ID

SO:0000392

Synonyms

• small nuclear RNA U2
• snRNA U2
• U2 small nuclear RNA
• U2 snRNA

Definition

U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing. http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00004

References

• http://en.wikipedia.org/wiki/U2_snRNA

Ontology

Sequence Ontology