Search Ontology:
GO: Cellular Component

PCSK9-LDLR complex

Term ID
GO:1990666
Synonyms
  • PCSK9.LDLR complex
  • PCSK9/LDL-R complex
  • PCSK9:EGF-A complex
  • PCSK9:low-density lipoprotein receptor complex
Definition
A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. (2)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes
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