Search Ontology:
GO: Cellular Component
NLRP3 inflammasome complex
- Term ID
- GO:0072559
- Synonyms
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- NALP3 inflammasome complex
- Definition
- An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. 20303873
- References
- Ontology
- GO: Cellular Component QuickGO AmiGO
- is a type of
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Phenotype
Phenotype caused by Genes