Delta4-3-oxosteroid 5beta-reductase activity

Term ID

GO:0047787

Synonyms

• 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity
• 3-oxo-Delta(4)-steroid 5-beta-reductase activity
• 3-oxo-Delta4-steroid 5beta-reductase activity
• 4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity
• 5-beta-reductase activity
• 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity
• 5beta-reductase activity
• androstenedione 5-beta-reductase activity
• androstenedione 5beta-reductase activity
• cholestenone 5-beta-reductase activity
• cholestenone 5b-reductase activity
• cholestenone 5beta-reductase activity
• cortisone 5-beta-reductase activity
• cortisone 5beta-reductase activity
• cortisone b-reductase activity
• cortisone beta-reductase activity
• cortisone delta(4)-5-beta-reductase activity
• cortisone delta4-5beta-reductase activity
• Delta(4)-3-ketosteroid 5-beta-reductase activity
• Delta(4)-5-beta-reductase activity
• Delta(4)-hydrogenase activity
• Delta4-3-ketosteroid 5beta-reductase activity
• Delta4-3-oxosteroid 5-beta-reductase activity
• Delta4-5beta-reductase activity
• Delta4-hydrogenase activity
• steroid 5-beta-reductase activity
• steroid 5beta-reductase activity
• testosterone 5-beta-reductase activity
• testosterone 5beta-reductase activity

Definition

Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates. 1.3.1.3

References

• EC:1.3.1.3
• MetaCyc:RXN-23672
• RHEA:54412

Ontology

GO: Molecular Function    QuickGO    AmiGO