non-canonical NF-kappaB signal transduction

Term ID

GO:0038061

Synonyms

• NIK-IKK kinase cascade
• NIK-IKK signaling pathway
• NIK-IKK-alpha cascade
• NIK/NF-kappaB cascade
• NIK/NF-kappaB signal transduction
• NIK/NF-kappaB signaling
• non-canonical NF-KB signaling
• noncanonical NF-kappaB signaling
• noncanonical nuclear factor kappaB (NF-kappaB) pathway
• p52-dependent NF-kappaB signaling

Definition

An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). (3)

References

• Reactome:R-HSA-5676590

Ontology

GO: Biological Process    QuickGO    AmiGO