tyrosyl-RNA phosphodiesterase activity

Term ID

GO:0036317

Synonyms

• unlinkase activity
• uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity
• VPg unlinkase activity
• Y-pUpN PDE activity

Definition

Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. (2)

References

Ontology

GO: Molecular Function    QuickGO    AmiGO