8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Term ID

GO:0035539

Synonyms

• 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity
• 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity
• 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity
• 8-oxo-dGTP pyrophosphohydrolase activity
• 8-oxo-dGTPase activity

Definition

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. (3)

References

• EC:3.6.1.55
• RHEA:31575
• Reactome:R-HSA-2395849
• Reactome:R-HSA-2395869
• Reactome:R-HSA-9750555

Ontology

GO: Molecular Function    QuickGO    AmiGO