Search Ontology:
GO: Biological Process

hippo signaling

Term ID
GO:0035329
Synonyms
  • hippo signal transduction
  • hippo signaling cascade
  • hippo signaling pathway
  • hippo signalling cascade
  • Salvador-Warts-Hippo signaling pathway
  • SWH pathway
Definition
An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. (3)
References
  • Reactome:R-HSA-2028269
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes
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