protein folding in endoplasmic reticulum

Term ID

GO:0034975

Synonyms

• oxidative protein folding
• protein folding in ER

Definition

A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).

References

Ontology

GO: Biological Process    QuickGO    AmiGO