super elongation complex

Term ID

GO:0032783

Synonyms

• ELL-EAF complex
• ELL-EAF-EBP complex

Definition

A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO